Ling Leng earned her Ph.D. in Traditional Chinese Medicine with a focus on cardiovascular diseases from Tianjin University of TCM. Her academic journey emphasized a multidisciplinary approach, integrating pharmacognosy, molecular pharmacology, and pathophysiology to explore natural product-based therapeutics. She developed expertise in identifying bioactive compounds, elucidating molecular pathways, and applying advanced analytical techniques. Her training also covered research methodology, biostatistics, and clinical translation strategies, enabling her to bridge laboratory findings with practical healthcare applications. Through rigorous coursework and research projects, she gained comprehensive skills in experimental design, data analysis, and scientific writing, forming a solid foundation for her impactful research career.
Ling Leng has built an extensive research portfolio in TCM-based cardiovascular therapeutics. Her professional experience spans laboratory investigations, clinical research collaborations, and interdisciplinary projects. She has led and contributed to studies exploring herbal formulations, plant-derived nanoparticles, and natural compounds in regulating oxidative stress, inflammation, and metabolic dysfunction. Working closely with multidisciplinary teams, she has been involved in designing experiments, managing research projects, and supervising junior researchers. Her collaborations with national and international partners have resulted in impactful publications. She also participates in peer review for scientific journals, contributing her expertise to maintain research quality in the field of pharmacology and TCM.
Ling Leng’s contributions to TCM and cardiovascular research have earned her recognition in both academic and professional circles. Her publications in high-impact journals such as Molecular Therapy, Phytomedicine, and Journal of Ethnopharmacology demonstrate her research excellence. She has been invited to collaborate on multiple multidisciplinary projects, reflecting her reputation as a trusted scientific partner. Her innovative work on plant-derived nanoparticles and cardioprotective herbal compounds has received attention in research forums and conferences. She has also been acknowledged by peers through invitations for journal reviewing and panel participation. These accolades reflect her standing as a leading figure in evidence-based TCM cardiovascular research.
Ling Leng possesses advanced research skills spanning experimental pharmacology, natural product chemistry, molecular biology, and nanomedicine. She is proficient in cell and animal models of cardiovascular diseases, applying techniques to evaluate oxidative stress, inflammation, lipid metabolism, and apoptosis. She has expertise in isolating and characterizing bioactive compounds, as well as developing plant-derived extracellular vesicles for therapeutic applications. Her skills extend to pathway analysis, meta-analysis, and bioinformatics for mechanistic exploration. She is adept at integrating traditional medicinal theory with modern biomedical tools to design effective treatments. Her work emphasizes translational potential, bridging preclinical findings with clinical application to advance cardiovascular health.
Publications
Sui, Y., Sun, X., Liu, Q., Qi, G., Yang, Y., Zhang, X., Francis, O.B., Wang, Y., Liu, R., Li, X., Jiang, M., Wang, X., Zhu, Y., Yang, M., Li, R., Li, X., Zhang, H., Wang, Q., & Leng, L. (2025). “Morifructus-derived extracellular vesicle-like nanoparticles regulate dyslipidemia and prevent atherosclerosis progression via miRNAs” in Phytomedicine.
Leng, L., Li, P., Liu, R., Francis, O.B., Song, S., Sui, Y., Yang, Y., Wang, Y., Sun, X., Miao, R., Yuan, Q., Li, X., Yang, W., Gao, X., & Wang, Q. (2025). “The main active components of Prunella vulgaris L. alleviate myocardial ischemia-reperfusion injury by inhibiting oxidative stress and ferroptosis via the NRF2/GPX4 pathway” in Journal of Ethnopharmacology.
Yang, Y., Owusu, F.B., Wu, H., Zhang, X., Li, R., Liu, Z., Zhang, S., Leng, L., & Wang, Q. (2025). “Mitochondria as therapeutic targets for natural products in the treatment of cardiovascular diseases” in Journal of Ethnopharmacology.
Miao, R., Guo, J., Huang, M., Ren, H., Liu, R., Sun, X., Francis, O.B., Wang, Q., Fang, S., & Leng, L. (2025). “Shengmai Yin alleviates myocardial ischemia/reperfusion injury via inhibiting Calpains expression” in Chinese Pharmacological Bulletin.
Wei, J., Leng, L., Sui, Y., Song, S., Owusu, F.B., Li, X., Cao, Y., Li, P., Wang, H., Li, R., Yang, W., Gao, X., & Wang, Q. (2024). “Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation” in Phytotherapy Research.
Tong, W., Leng, L., Wang, Y., Guo, J., Owusu, F.B., Zhang, Y., Wang, F., Li, R., Li, Y., Chang, Y., Wang, Y., & Wang, Q. (2023). “Buyang huanwu decoction inhibits diabetes-accelerated atherosclerosis via reduction of AMPK-Drp1-mitochondrial fission axis” in Journal of Ethnopharmacology.
Li, Y., Guo, R., Oduro, P.K., Sun, T., Chen, H., Yi, Y., Zeng, W., Wang, Q., Leng, L., Yang, L., & Zhang, J. (2022). “The relationship between Porphyromonas gingivalis and rheumatoid arthritis: A meta-analysis” in Frontiers in Cellular and Infection Microbiology.
Ling Leng’s career reflects a dedication to combining traditional wisdom with modern scientific rigor to address cardiovascular health challenges. Through her work at Tianjin University of TCM, she has contributed valuable insights into the therapeutic potential of herbal medicines and plant-derived nanoparticles. Her research not only advances the understanding of natural compounds but also opens new avenues for developing safer, more effective cardiovascular treatments. With a strong foundation in multidisciplinary research, a proven record of impactful publications, and ongoing collaborations, Dr. Leng continues to be a driving force in bridging TCM with global biomedical innovation for improved patient outcomes.