Samarth Life Science Private Limited | India
Author Profile
Suitable for this Best Researcher Award
Dr. Pratap G. K, a dedicated Research Associate at CSIR-CFTRI, has significantly contributed to the field of neurodegenerative diseases, particularly Alzheimer’s, through molecular nutrition and medicinal plant-based therapeutics. With a robust academic background and over 13 impactful publications, Dr. Pratap’s focus on bioactive compounds like crocetin showcases his innovative spirit. His studies on sphingolipids, oxidative stress, and amyloid toxicity present novel therapeutic avenues. His impressive research trajectory, national and international recognitions, and collaborations highlight him as a deserving candidate for the Best Researcher Award. His scientific curiosity and methodical approach are laying the groundwork for future breakthroughs in natural compound therapeutics and brain health.
Education
Dr. Pratap G. K holds a Ph.D. in Biochemistry (2017–2021) from Mangalore University, where he explored the neuroprotective potential of Indian medicinal plants like Olea dioica and Curculigo orchioides. His doctoral research employed both in vitro and Drosophila models to evaluate the plant extracts’ effects on Alzheimer’s pathology. He earned his MSc in Biochemistry (2013–2015) and BSc in Science (2009–2013) from Davangere University. Throughout his academic journey, he developed a strong foundation in molecular biology, biochemistry, and pharmacognosy. His educational trajectory not only sharpened his research acumen but also solidified his lifelong commitment to exploring plant-based therapeutic interventions for neurodegenerative diseases.
Professional Experience
Since June 2022, Dr. Pratap G. K has served as a Research Associate at CSIR-CFTRI, Karnataka, India, specializing in Alzheimer’s disease mechanisms. His research unravels the intricate pathways involving amyloid-beta aggregation, ROS generation, and sphingolipid imbalance. He has pioneered investigations using crocetin, a compound from wild edible fruits, revealing its potential to inhibit Aβ toxicity in SH-SY5Y cells. Dr. Pratap employs cutting-edge techniques like qRT-PCR, HR-LCMS, immunohistochemistry, and confocal microscopy. His use of both in vitro and in vivo models, including mice and Drosophila, demonstrates methodological rigor and innovation in exploring drug development routes for Alzheimer’s disease.
Awards and Recognition
- Fellowship, Alzheimer’s Association International Conference (AAIC®) 2024, Philadelphia, USA
- International Travel Grant, CSIR-HRD, Government of India, July 2024
- Research Associate Fellowship, ICMR, Government of India, 2022
- Best Poster Presentation, National Conference, Davangere University, 2019 Dr. Pratap’s accolades reflect his unwavering commitment to scientific excellence. From competitive national fellowships to international recognitions, his work is well-regarded by the global research community. These honors affirm both the originality and societal impact of his investigations into plant-derived neuroprotective compounds.
Dr. Pratap G. K exhibits extensive multidisciplinary skills:
- Molecular Biology: Western blotting, Tau prep, PCR, qRT-PCR
- Biochemical Analysis: Oxidative stress assays, TNF-α assays, HR-LCMS
- Cell & Animal Models: SH-SY5Y cells, Swiss albino mice, Drosophila models
- Neurological Focus: Aβ aggregation, PI3K/AKT/GSK3β pathway
- Software: GraphPad Prism, ImageJ, MS Office His comprehensive lab techniques and analytical precision allow him to decipher complex disease mechanisms and screen plant-derived compounds for neuroprotective properties.
Publications
Crocetin Inhibits Aβ Aggregation in Vitro and Reduces ROS Production and Aβ-Mediated Cellular Toxicity in Neuronal SH-SY5Y Cells
In Vitro Evaluation of the Neuroprotective Potential of Olea dioica Against Aβ Peptide-Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells
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Authors: Pratap G. Kenchappa, Yalpi Karthik, Poornima D. Vijendra, Raghavendra L.S. Hallur, Ajay S. Khandagale, Ashok K. Pandurangan, Sathisha G. Jayanna, Mohammed Ali Alshehri, Abdulrahman Alasmari, Samy Sayed, Manjula Shantaram, Muntazir Mushtaq
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Journal: Frontiers in Pharmacology
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Year: 2023
Neuroprotective, Lifespan, Memory Enhancing Potential, and Molecular Docking Studies of Natural Compound from Curculigo orchioides Gaertn.: A Study on Alzheimer’s Disease Model of Appl-GAL4 Drosophila melanogaster
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Authors: G.K. Pratap, Pramod G. Nagaraju, Ananda Danagoudar, Chandrashekhar G. Joshi, Poornima Priyadarshini C.G., Yasser Hussein Issa Mohammed, Lokesh Koodlur, Manjula Shantaram
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Journal: South African Journal of Botany
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Year: 2022
Ameliorative Activity of Medicinal Plant Fraction for Neuroprotection Against Acrylamide-Induced Neurotoxicity in Drosophila melanogaster—A Comparative Study
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Authors: G.K. Pratap, Danagoudar Ananda, Chandrashekhar G. Joshi, Manjula Shantaram
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Journal: The Journal of Basic and Applied Zoology
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Year: 2021
Anticholinesterase Activity and Mass Spectral Analysis of Olea dioica Roxb.: An In Vitro Study
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Authors: G.K. Pratap, S.A. Rather, Manjula Shantaram
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Journal: Indian Journal of Pharmaceutical Sciences
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Year: 2020
In Vitro Anti-Cholinesterase Activity and Mass Spectrometric Analysis of Curculigo orchioides Gaertn., Rhizome Extract
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Authors: G.K. Pratap, S.A. Rather, Manjula Shantaram
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Journal: Analytical Chemistry Letters
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Year: 2020